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Some of the patients in the studyalso had CSF collected before and after treatment. Chapter 4 in this text provides a review of the various localizationtechniques used in BoNT injections

Chapter 4 in this text provides a review of the various localizationtechniques used in BoNT injections. Wakeful-ness (lack of sleepiness), vigilance, and performance onmonotonous tasks deteriorate after a single sleeplessnight. Tau-positive, argyrophilic granular,and coiled bodies (oligodendroglial fi lamentous inclu-sions) are also widespread in the cortex and white matter.Another helpful diagnostic feature is astrocytic plaques(see Figure 2.14), which consist of a collection of tau-immunoreactive processes of astrocytes that surroundunstained neuropil and are frequent in premotor, prefron-tal, and orbital regions, as well as the striatum, caudate,and putamen. Radical oophorectomy withprimary stapled colorectal anastomosis for resection of locally advanced epithelialovarian cancer.

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